Moved to Endpoint Security
You can also exclude:
C:\Dir1\**.zip (it will exclude all zip files on Dir1)
Here's a good reference point: McAfee Corporate KB - How to manage file and folder exclusions in VirusScan Enterprise 8.x using wildcards KB50998
A single asterisk (*) wildcard can be used to denote single directory names. While double asterisks (**) allow a wider folder exclusion called a Multiple Depth Exclusion. These are exclusions where the same target folder name may occur multiple times in subfolders originating from a common folder.
Both * & ** are followed by a folder name ... Great way of testing any type of exclusion is with the EICAR file: McAfee Corporate KB - How to use the EICAR anti-malware test file with McAfee products KB59742