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we are runnign ENS 10.2 in our Citrix XenApp environment and also have a big impact on logon times. After updating from 10.2 to 10.5, it killed Internet Explorer on our XenApp Servers. So i recommend to be careful with this step
Did you consider the exclusions for Citrix?
Citrix Recommended Antivirus Exclusions | Citrix Blogs
We had the same issue. I followed Fabhoo's link, which solved it for us.