DLP Endpoint which has the ability to scan the local systems file system is the better solution for this.
Agree, DLP EndPoint is a "better solution".
But, is doing a Discover scan on a PC (versus a file server) possible?
If so, are there any details or processes to follow to do such a Discovery scan or are they performed in the same steps as I would do for a server?
DLP Discover supports CIFS and being C$ is technically CIFS, you could scan client systems with DLP Discover. This would be the same process as scanning a CIFS file server.