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As of now, it doesn't look like it:
Supported platforms, environments, and operating systems for ePolicy Orchestrator Technical Articles ID: KB51569 Last Modified: 11/4/2016
Not supported. ePO 5.9, now in beta, will the first ePO release to support Windows Server 2016.
I have 5.3.2 running on Server 2016 Standard.
as described under KB51569 Server 2016 is not official supported.
alexk999, there is a real difference with EPO if you are able to install it and if it is working probably and is also supported.
If you are installing EPO in a non supported Environment you will loose Support. It is okay for testing, but you should never do this in a productive Environment.