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In ePO 3.6.1 only Sites can be attached to OU's. Sites are the first level below Directory. Groups are sublevels of Sites.
ePO 4.0 allows you to attach any sublevel of the system tree to a OU, so that's far better.
You can change policies for your endnodes from your system tree. Actually it's the whole point of ePO... Just click Directory, than in the tab policies click on the activated policy for Access Protection below the version of virusscan you are using. If the activated policy is called McAfee Default, than it is read-only. You then need to create a new policy (f.i. My Default) and activate it on Directory.
Within the VirusScan policies, you need to specify policies for workstations and servers separately.
Please, if setting policies still is not clear to you: refer to the product guide because it contains any info you need about it.