Apparently you have to run the MS Application Compatibility tools against the programs and create an application compatibility DB to distribute. At least this is the solution for W7, I cannot say for sure about W10 since I just started researching similar issues when deploying updates/patches/installs via ePO. See my comment in the ePO section.
I would think McAfee has templates available for this, but I haven't found any when searching the KBs. Hopefully one of the folks who's been there/done that will chime in.
Not much help, but a starting point,
Curious - what version are you running: ePO/VSE/Agent? Also, are those products VSE/Agent installed prior to UAC GPO being applied?