Sig 6051 performs the similar functionality as the VSE Access Protection rule. There is no further documentation on it. The description you see in the Signature details is "This signature prevents McAfee processes from being hooked."
It is separate functionality from Sig 6010/6011, which are the app white listing signatures.
Sig 6051 exceptions will allow 3rd party applications to hook McAfee processes, which might cause issues (I don't have any specific examples though; testing would need to be performed in your environment; Sig 6051 is DISABLED by default as well). See if Bigfix has a way to prevent hooking (or some type of exclusion rules) of McAfee processes to alleviate the signature events.
All 33 HIPs AP rules are disabled by default. If you want HIPS to do the AP vs VSE you have to enable. HIPS 6051 triggers a lot more than the same rule in VSE.