TIE verifies the hash value of a file in virustotal and below steps that helps you to configure Virustotal in TIE under epo.
1. Configure the TIE Server Extension under Menu | Configuration | Server Settings | Threat Intelligence Exchange Server
2. Enter your VirusTotal Public/Private Key. Click Save.
For information on how to get the VirusTotal Public / Private key, please check How to get a VirusTotal public API Key
also look for the convicter thread in the community. The thread shows how to convict virustotal automatically if there is a TIE!Suspect event.