I know it's an old thread but I've gathered a list of ENS 10.5 resources/guides. Hopefully it will benefit someone and save few minutes of search.
Hello Andrew ,
Welcome to McAfee community. For sure you will get a great support and help inside the community. In community, your problem is not limited with the Tech Support boundaries.
Now coming back to your question. ENS is nothing but enhance version of VSE, SiteAdvisor and HIPS ( Probably IPS component is not added yet in ENS ) apart from this ENS is having some other detection mechanism like DAC , Real Protected etc.
From Antimalware protection you can use the VSE best Practise guide link is below apart from that McAfee has recommended some additional steps to protect your systems from Ransomware ( zero day )
List of and best practices for Endpoint Security Dynamic Application Containment rules
Please post us for any query.