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If VirusScan is blocking anything, it will say in the accessprotection.log, but i dont think it would be that. look at a client machine and see if the sitelist.xml server name/ip is what it should be and using the right port. your epo server has an static ip and hasnt changed right? since your able to ping, im assuming the local firewall on the epo server isnt on. are you using HIPS or McAfee's firewall? have you tried rebooting the epo server?
Thank you for your quick reply, I actually already found the issue and fixed it.
It turns out that the Mcafee Server Service wasn't running even though it is set to automatic. I didn't think of this at first because the EPO site was working fine. Anyway - I've been told before by the McAfee techs that if IIS starts first then it will interfere with the way the Apache service runs and cause issues with the way the agents connect to the server.
I stopped IIS, started Apache, then started IIS back up and everything now works fine!