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Great question! One of the tools that you can see the difference is called the McAfee Profiler. The tool is used on a system where performance is questioned. Usually someone is pointing their finger at McAfee being the cause. Execute the 'McAfee Profiler" and let it run for a period of time. That 'period of time' might be when you are, lets say, doing a backup. Measure a five or even 10 minute period to get a rough window of performance drain caused by the process that should otherwise be excluded. Do this before and after the exclusion is entered. The performance hog of the application\process\associated files will be seen before but shouldn't be seen after. You will now be left with an actual metric for a before and then after scenario. The McAfee Profiler will measure anything that is running during the capture period. Give it a run and let us know what you see.
Here is a link to get you going: McAfee KnowledgeBase - FAQs for McAfee Profiler
Thank you very much Jay. I will definitely be playing with the profiler more to get better understanding on setting up the scanning profiles.