Moved this to Consumer > General.
It should be possible as I was running it on this partition before I upgraded to Win 7.
Is Vista totally up to date including the latest version of IE ?
The software is very picky about that.
The product list shows the following OSs are supported
- Microsoft Windows 10**, 8.1, 8, and 7 (32-bit and 64-bit)
- Mac OS X 10.8 or later
Vista seems to have been Dropped
Ok found this
Windows Vista is not fully supported by current McAfee Windows Security Suites. Support is limited to Security Suite 14.0 R1. Intel Security will continue to provide best effort technical support for products installed on Windows Vista up to version 14.0 R1. This means that if a problem is reported and can be reproduced with 14.0 R1, it will be investigated. Otherwise, Technical Support will suggest moving to a fully supported environment.
I would expect you could install 14.0 on it best ask support