Are there errors relat to this in event log or in the MSMS product log (interface - settings & diags - product log)
If you look in Task manager there should be a process called "PsPickerx64Srv.exe" is this running with an account that has access to the SQL Database??
If not using an account with access or running with system account the OAS may not be working.
You can change the account details using SetSQLAct.exe
Run cmd prompt with full admin
cd down to <msms install folder>\bin
SetSqlAct.exe /USER=<username> /PASSWORD=<password> /DOMAIN=<domain>
You may want to test with Farm Admin first. You can change the account at any time using same tool.
Ensure again in task manager that the PsPickerx64srv is changed user - if not try stopping the service - ensure the process shuts down and then restarting service.
No trace log in event log
No trace log in msms log
"PsPickerx64Srv.exe" is runing with farm credentials.
Is it reproducible with any files or specific file(s) only??
Maybe you could consider
Stop McAfee Portalshield Service in services applet
Check task manager ensure following processes leave task manager or kill if they remain :-
safeservice.exe, rpcserv.exe(2), postgres.exe (several) & PsPickerx64Srv.exe
Set up debug logs in regist (or in ePO) - as service is not running local interface will be unavailable - use local folder such as c:\mcafee\debug
Start Service again - ensure the processes listed all rturn to Task Manager.
Perform upload of file that causes issue.
Open a case with support supply MER and debug logs
Also report any issue encountered - such like some processes did not dies from task manager or did not return on service restart.
When you deinstalled - did this leave behind the original install folder - default is c:\program files (x86)\mcafee\mcafee portalshield\
If you have other mcafee products install you probabl need c:\program files (x86)\mcafee
Make sure the old folder structure is removed for msms looks like is failing to write to <install folder>\bin
done by deleting <install folder>\bin and registry hlm\software\wow64\mcafee\portalshiel