It might help to see your deployment task. What versions of VSE and Agent do you have deployed?
The Advanced Threat Detection server is a separate product. It's a malware detonation sandbox that works directly with TIE to classify executable files. If you don't have an ATD server, you should not configure one here in the TIE config.
I have pushed agent 5.0.3 i believe as per the product doc the agent version should be 5.x . Do i also need to push VSE 8.8 along with TIE module for VSE to the endpoint systems ?
Endpoint systems: VSE 8.8 + TIE module for VSE + DXL client ? is this what goes in to the client systems ?
Oh yes. TIE module for VSE requires VSE. It's a module for VSE, so VSE needs to be installed first.
TIE for VSE only supports VSE 8.8 Patch 5 and up (or Patch 4 with a specific hotfix).