A little more information would help. I'm not really sure what 'ACCPAC' is. ACCPAC or any other product should have a list of recommended AV exclusions. My guess is that you want to find the process(es)) that ACCPAC uses and put then into the policy as 'Low Risk' which depending how configured will have little to no scanning.
Thank you for your reply. Yes it's the processes. I managed to find them but after configuring them as "low risk" I have realised that ENS10.1 does not like the application. I had to roll back to VSE8.8.