It is a legal migration path for you to simply upgrade to the 22.214.171.1243 agent. VSE would not have an issue with that.
What's unique to the 5.x agent, aside from the new Agent process names in 5.x, is that it installs our McAfee Controller service (mfemms.exe)
VSE doesn't use this service.
Thank you for your fast response.
And can I allready activate the ePO agent Key Updater ver 126.96.36.199 and MsgBus Cert Updater 188.8.131.52 for all the endpoints before I do the upgrade?
Hi, changing from Agent 4.x to 5.x take care! .-)
1) Agent 5.x is updating the SysCore component. So take a look if your installed McAfee products are compatible with this Version of the Agent.
2) Check your Access Protection Settings in VSE. If there are the self protection rules in place the new Agent processes are blocked. This can result in a complete damaged McAfee Installation.
3) If you are planning to upgrade from VSE Patch x to Patch 7 and Agent 5.x is already installed you should wait for Agent 5.0.3.x Release (Support Info). Agent 5.x often breaks a VSE Patch 7 Installation.
If you check your Access Protection Rules also check if you have Events where Access protection is blocking DAT Reputation. :-)
Additional you may take a look at this links.
Access Protection rules triggered when installing a VirusScan Enterprise hotfix or when performing a McAfee Agent upgrade
In their scenario they already have VSE 8.8 P7, which uses the same SYSCore version that MA 184.108.40.2063 is using; which means SYSCore is not going to be upgraded in this case.
However, it will introduce the McAfee Controller Service. They'll notice a new service is added to the system (along with the new MA 5.x services), called MFEMMS.exe.
I call it out because it does have an indirect functional impact to VSE, even though VSE doesn't use that service explicitly. So in that light it's something to be aware of, to test for in the environment, to ensure nothing odd comes out of the change from introducing that service.
Regarding your follow up question, my understanding is that the Master key is already built into your Agent package and only if you've changed that key then the Key Updater simply allows existing deployed agents to adopt the new key. In other words, you wouldn't have to do anything regarding ePO Agent keys, and if you did want to change the Master key, that could be done at any time.
But, I have to cite some ignorance here because Agent isn't my area of expertise.