I have the same issue for a few machines. Find out anything? I will try to get my hands on the next machine that has this condition. A couple of them we were able to solve via a McAfee Agent reinstall. I'm running MA version 22.214.171.1240 and MDE version 126.96.36.1999
Not anything really solid. One machine in question had windows updates installed and was just waiting for a reboot. Some policies would not apply until the reboot was completed.
Logging is less than great for these errors. Fully uninstalling PIP didn't seem to help at all.
In case it helps anyone, may have fixed this issue (nothing shows up in Queries&Reports anymore anyway..not sure why old entries are deleted?)
Updated agent to latest 4.8. Errors seemed to still be present. Figured out that Go extension and policy were not installed by the previous admin. Installing that and using even the default Go policy seems to correlate with the stopping of all the 2422 errors.
Oh..and also disabled mcafee dat reputation, which was failing on most endpoints anyway. With those three things, messages went away.