ENS 10.1 is managed from three different management options
1) ePO on premises (managed from a server)
2) ePO cloud server
if you are concern about ENS 10.1 modules to be removed from the control panel then yes you do have an option from under 1) and 2) where you can create uninstall deployment or task to remove the packages. you no need to manually uninstall or run a tool in the machine locally.
deployment from server or cloud will instruct the agent to remove the modules and uninstall the product completely without the end user knowledge itself.