Do you use distributed repositories, super agents, etc? I had the same issue on SA systems. Resolved it by changing the replication and turning off the Lazy Caching.
Testing turning off Lazy Caching now for the superagents....frustrating - issue wasnt there for the 4.8.1500 agent
It stops the replication from occuring every day....I restart, it works, next day, its not replicating again - go in and have a look, 100% cpu for macmnsvc.exe
Will update once I restart and test again tomorrow.
Turning off Lazy Caching appears to have worked perfectly. Replicated without issues this morning.
Which is good as one of them was an Agent Handler also and I really couldnt have them chewing 100% cpu all the time.
Turns out to be a confirmed issue with Agent 5.02. McAfee recommends downgrading to 4.8. All our SuperAgent systems are now back at 4.8 with Lazy Caching enabled and this works much better. We're not replicating anything that doesn't need to be.