The following McAfee kb articles show the current information.
EPO 5.3 supported products
Supported operating systems for McAfee products
DLPe 9.3 or later for 5.3 support. At this time there has been no announcement of what version will support Windows 10 and no release date. The above article - as noted - will update when it's announced and an SNS will be sent out at that time.