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Without agent to server communication enabled the agent will not pass its properties to the epo server and will not take its policies from it. not something you really want to disable.
The manual puts this like this:
[LEFT]During agent-server communication, the agent and server exchange information using SPIPE, a proprietary network protocol used by ePolicy Orchestrator for secure network transmissions. At each communication, the agent collects its current system properties and sends them to the server. The server sends any new or changed policies, tasks, and repository list to the agent. The agent then enforces the new policies locally on the[/LEFT]
Disabling the ASCI via policy makes only sense if you create an agent wakeup call task before.