We installed the ePO management Extensions last week and I have not seen any adverse effects.
The DAT Reputation Status refers to the published status of the DAT which is retrieved by each endpoint from GTI (Global Threat Intelligence - McAfee Cloud).
This just indicates that the DAT has not be marked good or bad.
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Certified McAfee Product Specialist - ePO
In our test environment, we have installed the DAT reputation and had kept both the compenents ON but machines are not able to download the "Bad" DAT (2001). I am also clueless about the same. I checked the GTI server nslookup as well with following results. Can someone help me on this?