Please refer to the following thread that has similar issues:Schedule Scan runs 14+ hours In addition, you may try running the MVT to see if it detects any issues.http://mvt.mcafee.com/mvt/en-us/downloadindex.html
I might add also, you can open your McAfee User Interface, and click Navigation/ General settings and Alerts/ and expand. Then remove check in the box to "Wait until my PC is idle" to run scheduled tasks like Scans/Automatic updates/Quick Clean.
However you have to make certain that your scheduled scan is set to run at a time you know you are not going to be using your Computer, but still on/not off and allow it to run and complete.
Or you can turn off your scheduled scan altogether , and run a On Demand Scan once a week, or when you elect to do so.
Please kindly apprise us if your issues get resolved ,or need further assistance.
All the very Best
McAfee Community Moderator
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You can also turn off the auto-scan by opening SecurityCenter, in Virus and Spyware Protection click Real-time Scanning, in the next window click Scheduled Scans and turn that off there. No need to turn off protection, simply do a scan when you want to and with a Custom scan you can opt for various different ways to do that.
Actually I would try the suggestion to turn off "Auto-Scanning-Scheduled Scanning" first and then do a restart. See if that resolves your issue. If so, simply Right click on your McAfee Icon in your lower Task Bar, beside the clock and run a scan when you want to.