Hi kiran30, Welcome to the Community
If I read you issue correctly, you are able to connect the McAfee Data Centre Connector for vSphere to a vCentre instance in the same Data centre, but are unable to connect to a vCentre instance n an other Data centre.
This sounds like the TCP/IP communications from the ePO server to your xyz vCentre instance are failing.
Are you able to check if your Firewalls are prevent the ePO server from connecting to your xyz vCentre instance, by default the Data Centre connector uses port 443 (https).
Certified McAfee Product Specialist - ePO
Thanks for the response.
The mentioned issue has been resolved. There were no any issues with the Firewall - I was able to telnet the ports. Issue was with the MTU settings on the ePO server. As per Windows standard - default MTU is 1500 on any network interface on the server. I changed the value to 1360 and now all my VCs are connected to ePO.
However, Still I'm checking for the network issue that why communication was not working on 1500 MTU?