4.5.0 Build 851 is patch 1
you can upgrade from McAfee ePO 4.5 Patch 3 (build 937) or later to 22.214.171.124
The best soultion is just upgrdae the version to 4.5 latest version and then go to 4.6.8 .
good luck !
The 4.5 install sets may no longer be available, though - if this is the case, I would open a case with Support: although 4.5 is end-of-life, since the goal here is to get to a supported environment they should be able to provide the last 4.5 patch install. As nteferi says, from there you can upgrade to 4.6.
I was able to find patch 7 to 4.5 and that was just what I needed to have in order to upgrade to 4.6. Thanks to all for their input!!