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It all depends upon your OS. In Windows Vista/ 7 it is compatible. In Windows 8/8.1 it is not, as it contains Anti-Virus Capabilities. For those whom continue to run Windows XP, it is also Compatible.
If it is windows 7 Mcafee will accept it being there
In Windows 8 and 8.1 (& above) the installation of any antivirus should automatically disable Windows Defender altogether as it contains an antivirus of its own in those systems and running two together could lead to trouble
Sorry CD posted same time at least that gives the OP 2 same opinions