desktop.ini is a windows system file deleting it will get windows to re-spawn it.
Some malware infect this file so to be sure run several of the scanners I mention in the free scanners link in my signature.
With Malwarebytes do not install the premium trial its real time scanners could clash with McAfee install the free version. With getsusp add your email address to the program's preferences so McAfee can update you if they find anything
Also if you are worried post the desktop.ini files to www.virustotal.com and see if there are any detections as well
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How To Uninstall/Reinstall McAfee Consumer Products EXCEPT Anti-Theft
How To Submit A False Detection To McAfee
Free Anti-Spyware/Malware/Hijacker Removal Tools
I think I may have found you something reasonably useful. After sifting through numerous articles that yielded zero, this one had the most positive responses. Maybe it will help and it has pictures to assist along the way. Please read through the entire article so you don't get stuck unnecessarily on step 5. Some folks figured what needed to be done ultimately and everyone was happy. So go slow, especially around the registry mentions.
You may try this Reliable/Proven Removal Guide which includes some of the Superb Tools PK suggested
In addition, You quite possibly will find this Article created by Fellow Moderator Hayton to be most informative. You can never be (Too Safe) when downloading from the Internet.How you get tricked into installing Potentially Unwanted Programs
Wishing you all the very Best,
McAfee Volunteer Moderator 1
Edited: By Catdaddy to add more Content
I might add, a very interesting/Informative Article. As you stated, one has to be very observant when tinkering with "Registry Items" Not everyone is as "Tech Savy", if you will.
All the Best,