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Ok, going to kick myself on this one, but I have one host where the agent refuses to talk to the epo "error fail to com with ePO" and I'm logged onto the ePO on that host, able ping, ect.
Installing a new agent still doesn't fix the problem.
Runing HIPS 8p4 IPS on, FW off
SolidCore with both change control and app control in monitor mode.