We have 1500 macs in our fleet and we exclude the following:
/Users/.*/Documents/Microsoft User Data/Office 2011 Identities/.* (Outlook identities database to prevent constant rebuilds)
/.*\.vmdk (Fusion VM Files)
/.*\.pvm (Parallels VM files)
/Applications/.*/Contents/(version|Info).plist (plist files)
/System/Library/Spotlight/.* (Spotlight indexing)
We also have some specific extension excluded for files standard with our industry (media audio and viseo files for the suite of production tools we use), but the above are our standard exclusions.
Certified McAfee Product Specialist - ePO
McAfee put out a recommended "best practice" exclusion list, as well. You can find it in the 2.x Product Guide.
Looks life you've configured some of these per previous suggestions. Depending on corporate security policy/risk acceptance, you may want to exclude email database files, as well. Risk should be minimal with this if you have an email gateway product with AV scanning on your perimeter.