Which folder or which application are you seeing this in?
The answer to your question is, that Autoruns is an invaluable tool in locating malware processes that run at startup. It's one of the most useful programs that Mark Russinovitch has created, and he's created quite a few.
For some information about Autoruns see the Microsoft Sysinternals download page at
For a 2004 article by Mark Russinovitch about Autoruns see
And you might learn something from the Autoruns forum at