What's the question you are asking? If 22 virus scanners report the file as bad, then there's a high chance it is.
I am guessing this is a cheat file for the Payday2 game?
its not a cheat file, its a file for inproving the basic Hud of the game
Never had problems whit it, and just today it seemed to be a Wrong file
secondly i use it as a anti-cheat that is build in so other team mates cant change ingame values
or the personal stats like Rank achievements 'ingame credits''
The site "hostr.co" is blacklisted by TrustedSource and SiteAdvisor. Trying to get hold of a copy of the file from the link that you provided was difficult but I managed it.
Edit : A page briefly appeared before SiteAdvisor kicked in, with a file name and a 'Download' button. The name of the file was "HoxHud-P1-Manual-install.7z" so that's what I downloaded.
Chrome didn't object to the download so I then uploaded the file to VirusTotal and ran a fresh check. The file is still marked as malicious by 19 out of 54 anti-virus engines but not - now - by McAfee nor by Microsoft, and those are the two I look for first.
Google Safe Browsing says the site has recently hosted malware, which probably accounts for the TrustedSource rating.