This would be the KB article to start with
and in reference to your particular issue
There is no virus scan console that gets installed on any of the clients that is mentions in the KBs to add exclusions. Jus the McAfee Security as a service app that allows you to scan or view product details.
our McAfee product is: McAfee SaaS Endpoint Protection.
where as the KB the talks specifically about backup exec is directed towards McAfee Enterprise.
Is this not a option for Endpoint protection?
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For file exclusions
But this KB article would suggest that process to ePO and SaaS is the same.
i also noticed a check box option in the policies > virus & spyware protection > advance settings > "enable on-access scanning (if disabled) the next time client PC checks for an update"
would this cause backup execs processes to slow down?