Are all boxes failing to update, or just some?
If it's all, it could be a problem at the ePO server end, so it might be worthwhile to reboot it and try again.
You're running ancient McAfee Agent (current is MA 4.8 P2) and Virusscan (Patch 1, current is Patch 4).
And make sure you've deployed the 5600 Engine.
Before rolling out VSE 8.8 Patch 4, read the following threads:
Otherwise make sure there's enough free space on your PCs' C: drive.
C:\Windows\Temp is possibly full of failed DAT downloads