You could exclude the ePO install directory; however, unless you have a fairly substantial deployment base I don't think you will notice any difference in performance with or without the exclusion.
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You can go through the follwoing Kb Article to check the Consolidated list of VirusScan Enterprise exclusion articles
KB66909 - Consolidated list of VirusScan Enterprise exclusion articles
Please update us if the above article was useful.
Thanks in Advance.
AJ reminds me of an angle I hadn't thought of. I was focused on the epo server. But my laptop with McAfee encryption would need exclusions as well in a production environment as his linked article points out.
I think an eval I'm going to go with jstanley, and just leave it alone.
I appreciate the help.