Yes, you can disable the antivirus.
In my case, I've created VSE policies on ePo policy catalog to disable the antivirus.
When do you want to disable it, You go to the system tree and apply the disabled VSE policy to the selected system and apply it.
The policies where I've disabled are :
- On-Access General Policies
- On-Access Default Processes Policies
- Access Protection Policies
- Buffer Overflow Protection Policies
I hope that helps you.