I would set artemis to medium to start with, that probably accounts for about 20-30% of our detections and we have not seen any false positives (although I would spot check it!).
Also there is a best practice guide for VSE that I followed that may help, for example using the high/low risk and default groups. So you can spend more time scanning internet explorer than some internal program.
hope that helps!
Please go read and implement that set of Minimum Requirements. The DAT file itself is one of the least important things you can do. There are several policy settings that are absolutely crucial.