I verified, that for "Download Botnet Detectors", the NSP Manager 188.8.131.52 do not use predefined proxy server and tries direct https connection. All other downloads are still ok via proxy. (Download IPS signatures, Device Software ...)
I modified our FW rules temporally to allow direct https connection. Hope McAfee can confirm this issue and correct.
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We have duplicated this issue and are working on a fix. In the mean time, allowing the botnet connection directly to the server gti-api.mcafee.com or manually downloading the detector updates should work.