I experienced same issues when i tried upgrade so left at the end. no luck at all.
Followed all kbs.
This is the failure pointe:
ErrorString=FAILURE: In ServiceStopService to stop service [MCAFEETOMCATSRV250] with return code [-1]. Failed in InstallScript file [C:\CodeBases\isdev\Script\ISRT\Src\Service.rul] line number  with error code [-1].
Please follow the following KB Articles, Religiously and then try to upgrade and update the Post -
- Go through KB71825 - ePO 4.x installation / patch upgrade checklist for known issues
- Also go through EPO 4.6 Installation Guide.
- Make sure that all Agent Handlers are diabled(if any) and all the Server Task at EPO are Disabled., No Client Task is scheduled to Run at the Time of EPO Upgrade.