Some advanced malware programs have the ability to kill or disable anti-virus programs. It's one of the first things they do once they start running. If you've got one of those I doubt whether SuperAntiSpyware by itself is enough to clear the infection.
Have you tried using System Restore to get a working configuration from before this happened? That should be the first thing to try. If it works you may need to update Windows, McAfee and any other third-party programs that have had recent upgrades (I'm mainly thinking of Java). Whether it's fully successful or not you should then run a couple of scans from other vendors just to see if they find anything. I prefer Microsoft's Live Safety Scanner and Malwarebytes Free; others have their own preferences.
If Malwarebytes is blocked by malware they have a free tool called Chameleon (which I've never had to use so can't give advice about) - see this page for details.
If either of the above 3rd-party programs detect an infection it would help us to know what it was - they'll have their own names for it. Anything that can disable an AV program needs to be found and if possible trapped so McAfee can analyse it. If they don't find anything we'll have to look at other possibilities - a messed-up McAfee installation is of course one of them.
Still, try those steps and let us know how successful they are.