Could you be a bit more specific for me on the following questions?
You say "McAfee scans this server." Does that mean with the On Access Scanner or the On Demand Scanner?
The exclusions you list seem to be Linux/Unix style directories? Yet VSE is a Windows product.
Is there an actual detection? Do you get some actual file quarantined? (If so we can go down the path of getting it reviewed for possible false)
Or is this just some type of "freeze"?
Generally speaking I wouldn't exclude all those file types. Doing so globally would be suicidal. Doing some of those for one server might be okay. But there are probably better ways of doing this.