First check this Registry key in your machine.
[HKEY_LOCAL_MACHINE\SOFTWARE\Network Associates\ePolicy Orchestrator\Application Plugins\EPOAGENT3000
If missing redeploy your agent. if present try this.
Be sure that you are using MA 4.6 for windows 8.
1) Stop the framework service
2) Delete the following files from the agent data folder:
3) Start the framework service again
4) Send a wakeup call to the machine
Confirmed i am running MA 22.214.171.12422. What you mentioned made me confirm this is happening on both 32 and 64 bit windows 8. Only the serverDefault.xml was present in agent data folder. I removed the file and restarted the service to no avail.
I have noticed that everytime it checks into the server, it's reporting "New Site Listfile was received".
1.Disable UAC on windows 8.
2 Stop.McAfee frame work service
3.Assgin Everyone to Full control to the folder 'Common framework' (\Documents and settings\All Users\Application data\McAfee\),
4. start the framework service and initiate ASCI.
5.UPgrade your agent extension asw ell in ePO.
6.Also let me know what Package are there in MR which are not being downloaded.
Please make sure that you have the latest version of the agent checked in, which I think you have, and - most important - that you have checked in the latest agent extension. The extension tells ePO which platforms are supported, so it may be that an older extension is not recognising Win8 as a supported OS.