This is not something that has ever been tested unfortunately. The EEPC product though has a boot manager in it though - you won't be able to use GRUB as it does not support relocation, and neither does the EEPC boot loader.
You'd have to try it and see.
Not sure that I understand/appreciate the relocation issues but I was hoping that with low level encryption via OPAL in the disk HW everything running above would be transparent (and encryted).
Unfortunatley, OPAL does not really work like that - it uses separate encrypted and unencrypted ranges of the disk for different things.
You still need a boot manager though to allow you to pick which partition to boot from, and the only one which has a chance of working is the one built into EEPC.