10053 & 10054 - These are just standard windows/winsock error codes, and don't provide much depth other than 'it's a network problem'.
It's really hard to say what might be the root cause without further data.
If you are still experiencing problems it may be worthwhile opening a support call so that some additional troubleshooting can be done.
Also we are getting these sort of errors
Failed to connect, error 11004 ( The requested name is valid, but no data of the requested type was found.
The moment i add the hostname & ip of the machine or epo server in the host file. It starts replicating fine. There around 150-200 reps deployed. Pratically it wont be feasiable to modify these files on all of them. Pls let me know the issue related.