Moved to Malware Discussion > Home User Assistance for better attention.
Your first weapon would be to initiate System Restore to before all this started. If you can't do it in regular mode simply power off and reboot into Safe Mode and try starting it there.
Second weapon would be to try Stinger and Malwarebytes Free, both linked in the last link in my signature below.
They can be downloaded to your desktop if necessary in Safe Mode with Networking and if you "Save as" and change their names in the process the malware shouldn't prevent them being run in regular mode.
However Malwarebytes Free can also be installed, updated and run in Safe Mode with Networking if necessary.
I've been searching my favourite anti-malware forum for guides on this one and this is the nearest they get: http://www.bleepingcomputer.com/virus-removal/remove-vista-security-2012
(They do have one for Vista Defender 2013 however).
You might want to look at the Hijackthis section in that last link in my signature and post a log on their forum. The address is given below the Hijackthis link.