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Why not disable McAfee and see if the problem exists? Because what you descibed
is a real nightmare, but it's not said that mcafee was the cause?
Its too much of a coincidence that it only affected servers that were running Mcafee and also I have read another post on here that DNS issues were experienced when another user installed patch 2. My servers also had this problem at the same time the patch was installed. It caused me no end of problem on Monday morning but thankfully everything was OK today. Lets hope it stays that way.