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There are three things you need to take into consideration:
1) Are you running base 8.7 or Patch 1 (or Patch 2 now it's been released)? - Patch 1 itself had some performance improvements
2) What are the specifications of the PCs your users running? Theres no magic bullet for making an underspec PC run 8.7 fast if it doesnt have the juice.
3) Have you noted the most common used CPU intensive processes to consider making a list of exclusions? We cant suggest exclusions for programs your company runs.
What are some of the windows files that can be added as an exclusion?
Being sure to follow up with at least a weekly full scan of the drives to catch anything that may have infected (written to disk) the system prior to a newer DAT update.
Typically there are 4 to 8 reads to every write, depending on the system. Unchecking "When reading from disk" saves anywhere between 4 to 8 scans of files which I find is a tremendous improvement in performance given that the vast majority of infections, in my experience, are caught during a Write operation.
Just my thoughts, for whatever they are worth.
Anyone else out there who can offer some exclusions for any windows file it would be greatly be appreciated.
On servers I use the settings advised by previous poster, with weekly full scans.
On desktops I scan on both read and write operations, no weeks scans as it is a 24/7 operation.
That is my suggestion, but what rmetzger said would definatley be better performance wise.