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OK, so what I might do would be to bring a single system under your control back to the default McAfee VSE settings. Then one (1) parameter at a time, increase the 'Access Protection policies' testing their affect on getting Microsoft Updates. (Alternatively, change this PC from it's current policy back on 1 setting at a time until you isolate which one is causing MS Updates not to function properly.)
Once you have isolated that policy change, I would test it on a user's environment for say, 1 month, past Patch Tuesday. Once convinced of this policy change, broaden the scope out somewhat and see how things go for those that did not get their updates recently, and document how things went.
I know this might not be the answer you wanted, but I hope it is helpful.
That makes sense, thanks Ron.
I'm actually waiting on Patch 2 and I'm going to try out the Artmeis thing to see how well it works if I enable in the On Access scans and the On Demand scans.
Hopefully it'll protect us against the common threats I've seen so I can leave the Access Protection settings to the Standard Protection defaults (with a few exceptions).