Exclusions will probably resolve your problem
http://support.microsoft.com/kb/961804 - for some suggestions from Microsoft
https://community.mcafee.com/message/131115 - The post from user Parachute lists the exclusion they use on thier HyperV cluster.
Basically you know the files are 'safe' as they are specific HyperV files therefore you can exclude them and prevent VSE scanning them.
moved to VSE forum for better attention.