Is this Total Protection home product or Total Protection Service (ToPS or SaaS)?
Exclusions from VirusScan real-time scanning have not been possible since VirusScan 7, some 7 or 8 years ago. You can make exclusions from a manual scan or a scheduled scan but not the built-in protection. We Moderators have been asking for that feature for a long time as have customers via the Product Ideas section.
If software is being misidentified as malicious then follow the procedures here: https://community.mcafee.com/thread/2016
If this is in fact ToPS then I will move the thread accordingly.