You won't need to reinstall VirusScan, you will need to change the McAfee Agent to a 'managed' state.
(The agent exists with VirusScan already in an unmanaged state, as this is how dat updates are applied.)
There's quite a few ways of achieving this, mostly covered in the ePO product guide which is good starting point for getting a grip on the intricacies of ePO.
McAfee also posts the same guides and video tutorials on the service portal site (https://mysupport.mcafee.com/Eservice/Default.aspx).
I think you can find these video tutorials on youtube too if needed. They are a very good kickstart.
Finally, if you use ePO 4.6 there is a built-in guided section after installation finishes that does exactly the same and walks you through the first steps of machine management.
If you find you do need to uninstall/reinstall VSE, yes ePO can do that too. Should not be necessary though.
Thats great, we were hoping that would be the case. Thanks for the information.